

It is well tolerated even for long-term therapy and its tolerability is optimal. Pantoprazole is significantly effective both for acute and long-term treatment with excellent control of relapse and symptoms.

PPI have minimal side effects and few slight drug interactions and are considered safe for long term treatment. They are considered safe and more effective than histamine receptor antagonists for healing esophagitis and for preventing its recurrence using a long term maintenance treatment. Proton pump inhibitors (PPIs) are central in the management of GERD and are unchallenged with regards to their efficacy. Older patients often complain of less severe or frequent heartburn than younger patients and they may present with atypical symptoms such as dysphagia, weight loss, or extraesophageal symptoms. The prevalence of gastroesophageal reflux disease (GERD) increases with age and elderly are more likely to develop severe disease.
